• By The Financial District

U.S. FDA Okays Sale Of Generic, Cancer-Killing Israeli Drug

The US Food and Drug Administration (FDA) has approved a groundbreaking, complex, generic drug for the treatment of ovarian cancer, multiple myeloma, and Kaposi’s Sarcoma, Maayan Jaffe-Hoffman reported for Jerusalem Post.

Photo Insert: Doxorubicin-HCI Liposomal Injection will now be available in the US market.

Ayana’s Doxorubicin-HCI Liposomal Injection will now be available in the US market. The drug is a modified chemotherapy treatment that targets cancer cells directly, thereby reducing side effects.

The drug was developed by Prof. Yechezkel Barenholz, a world expert in biochemistry, nanotechnology and drug development and the winner of the 2020 EMET Prize for exact sciences. Barenholz is also the inventor of Doxil, the world’s first nanotechnology drug approved by the FDA in 1995.

Doxorubicin-HCI is the generic version of Doxil, which had first been produced by Johnson & Johnson. He has written over 420 scientific publications and owns more than 55 patents.

The treatment leverages the drug doxorubicin – a cytotoxin or chemotherapy drug – encapsulated in a closed lipid sphere called a liposome. A liposome can be imagined as a small “ball” the size of a virus, explained Barenholz. The ball is made of an envelope made of special “fat” molecules with a watery solution inside. These balls are referred to as nano-liposomes.

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“We load the toxic agent into these balls and infuse them into a patient’s bloodstream once a month,” he said.

“These nano-Liposome balls travel through the bloodstream until they reach the cancer tissue and there, through tiny pores in the blood vessels, exit the bloodstream and accumulate in the cancer tissue.

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“Unlike healthy cells, cancer cells produce ammonia, and this ammonia releases the active toxic agent [doxorubicin] out of the nano-liposomes balls in proximity to the cancer cells, leading to the cancer cells’ death,” Barenholz explained.

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